glutathione peroxidase

Short name=GPx-1
Short name=GSHPx-1
EC=1.11.1.9
Protects the hemoglobin in erythrocytes from oxidative breakdown.
Catalytic activity
2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subunit structure
Homotetramer. Interacts with MIEN1.
Subcellular location
Cytoplasm.
Post-translational modification
During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine By similarity.
Sequence similarities
Belongs to the glutathione peroxidase family.